USMLE (United States Medical Licensing Examination) Step 1 Practice Exam

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What is the primary medication associated with increased bone mineral density due to enhanced calcium absorption in the distal convoluted tubule (DCT)?

THIAZIDES
Beta Blockers
ACE Inhibitors
Calcium Channel Blockers

The correct answer is: THIAZIDES

Thiazides are the primary medication associated with increased bone mineral density due to enhanced calcium absorption in the distal convoluted tubule (DCT). Thiazide diuretics act on the distal convoluted tubule in the kidneys to inhibit the sodium-chloride symporter, which leads to enhanced calcium reabsorption. This increased calcium reabsorption results in higher serum calcium levels, promoting bone mineral density. The other options, including Beta Blockers, ACE Inhibitors, and Calcium Channel Blockers, do not have a direct effect on enhancing calcium absorption in the distal convoluted tubule and are not associated with increased bone mineral density.